Musculoskeletal disorders are among the most common causes of pain, joint stiffness, reduced mobility, and impaired quality of life. These conditions can affect individuals of various ages, particularly middle-aged and older adults, people engaged in physically demanding work, and those with sedentary lifestyles. Research into supportive approaches for relieving symptoms, improving physical function, and enhancing quality of life plays an important role in advancing community healthcare.

Through clinical assessments, standardized pain scales, functional mobility tests, and objective outcome measurements, the study aims to collect scientific evidence regarding the product's efficacy, safety, and tolerability. VIỆN HÀN LÂM Y HỌC warmly invites interested individuals to participate, contribute to scientific research, and support the development of evidence-based solutions for musculoskeletal health.

The study is expected to focus on evaluating the following potential benefits:

• Musculoskeletal Pain Relief: Assessing changes in pain intensity in commonly affected areas, including the neck, shoulders, back, lower back, and knees.
• Reduction of Joint Stiffness: Monitoring changes in joint stiffness, discomfort, and mobility difficulties, particularly after periods of rest.
• Improvement in Joint Mobility: Evaluating changes in joint range of motion and ease of movement during daily activities.
• Improvement in Musculoskeletal Function: Assessing functional abilities such as walking, standing up, sitting down, bending, and performing activities relevant to the affected joints or muscles.
• Reduction in Pain-Related Daily Limitations: Monitoring the impact of pain on sleep, work performance, and everyday activities.
• Improvement in Quality of Life: Evaluating changes in physical functioning, comfort, daily independence, and participants' perceived well-being.

In addition to evaluating potential benefits, the study will assess product safety, tolerability, and any adverse reactions throughout the study period.

Interested volunteers will undergo preliminary screening to determine their eligibility based on their musculoskeletal condition and the study's inclusion and exclusion criteria.

• Adult men and women aged 18 years or older.
• Individuals experiencing muscle or joint pain or symptoms associated with musculoskeletal disorders.
• Individuals with recurring discomfort in the neck, shoulders, back, lower back, knees, or other joints.
• Individuals experiencing joint stiffness, reduced mobility, or difficulty performing everyday activities.
• Individuals whose overall health and musculoskeletal condition meet the study's eligibility requirements.
• Individuals willing and able to follow the product usage schedule and attend all required assessments.
• Individuals who voluntarily agree to participate and meet the study's inclusion criteria.

Participants will receive:

• Initial screening and professional musculoskeletal health assessments according to the study protocol.
• Evaluations of pain intensity, joint stiffness, range of motion, and physical function using appropriate clinical assessment methods.
• Necessary examinations and assessments as specified in the study protocol.
• Study products or comparator products according to their assigned study group.
• Professional guidance, monitoring, and follow-up assessments throughout the study.
• Protection of personal information and research data in accordance with applicable regulations.

• Study Duration: According to the approved research protocol and study schedule.
• Location: Ho Chi Minh City, Vietnam.
• Research Organization: VIỆN HÀN LÂM Y HỌC (Academy of Medical Sciences).

Interested individuals are invited to contact VIỆN HÀN LÂM Y HỌC for registration and preliminary eligibility screening.

Detailed information about the study product, research procedures, potential benefits, and possible risks will be provided before volunteers make an informed decision about participation.

Participation is entirely voluntary. Volunteers have the right to decline or withdraw from the study in accordance with applicable regulations. Registration does not guarantee eligibility or any specific improvement in symptoms.

The study product is being evaluated for its potential supportive benefits and is not intended to replace necessary medical treatment.